Remove the and from the sentence and it makes more sense. The machine guns or firing as the kreeper climb the wall otherwise you need a third thing that’s happening as the machine guns fire and the kreeper climb.
As the Kreeper climbed the wall in hordes, and the machine guns fired at the vertical limit firing at ninety-degrees, killing hundreds and yet still they climbed.
Several hundred years in the future, post-Prima-Uplift Earth is a rural paradise, and like any twenty year-old raised in the backass middle of nowhere, Ariadne Westland is looking to get the hell off this rock . . . by any means necessary.