A West Virginia woman must use her grandmother’s Appalachian folk magic to save her ex from an opioid overdose.

The story of Cassidy, cam girl in modern-day SoCal; Paloma, Fulbright scholar in newly Westernized Prague; Jane, farm girl working at the FBI in DC during WWII. Each leaves Appalachia to find a new life, only to be pulled back to the land they know.